Synda - I am on year two of the denufosol study and have two blog entries about it - search "denufosol" and you'll find my comments. I did the year long blind study - my pfts didn't budge, so I assumed I had the placebo (or if I had the drug, it did nothing for me).

Now I'm in the second half where I'll do the drug for at least a year (if I go off the study, it will be because they need me more for a different study). I don't notice a taste, but I do notice that I feel a little more "slippery." I never really cough up much, but what I do cough up certainly seems thinner.

and YES, the PFT laptop sized machine they use for the study consistently shows my percentages as lower than with the jumbo, full-size pft machine the clinic uses (and it drives me nuts). After three months on the actual drug, the percent predicted only showed a 3% increase . . .and I was not happy. But then my CF doctor showed me that the FEV1 had actually jumped a significant amount - and the docs were going to contact the study to see what criteria they were using to calculate percent predicted.

So now I am going to try to remember to keep a log of the actual numbers . . . not the percent predicted - to satisfy myself that this is working, more than anything else!

Where are you doing your study? I'm at Northwestern in Chicago.